If you hold option and click the '-' tab it resets the printing system. In System Preferences>Fax & Print, Right click or Control+click on the Printers list Sidebar, choose Reset Printing System. did you Rest the Printing system on the Mac? We have deleted the printer from System Prefs, rebooted, and added it back.

I attached directly to a USB port on my MacBook Pro.

R & R the Epson Drivers, Clear the Printer 'stuff' on the Mac, Reinstall drivers from the Epson website, Mac wants to update the 'newest' Epson Drivers (kinda' funny when I think about it.).

When 'Printing' from within any application (firefox, TextEdit, winders.) The job starts to queue, but errors before engaging the printer.

In 'Settings', when you select Print/FAX and print a 'Test Page' - Success! This is a process that invokes the Epson Driver directly.This is a USB printer, connected directly to their Mac.The printer is connected (directly), shows up in the printer list, can print a test page, but won't print any document from this computer (it's fine from my laptop). I'm helping someone with a printer problem, and I have a mystery on my hands.

Print test page hp 2135